Hidetoshi Kumagai Selected Research

Leukemia

4/2005	Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis.
8/2003	Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

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Hidetoshi Kumagai Research Topics

Disease

5	Myocardial Infarction 06/2021 - 04/2016
3	Inflammation (Inflammations) 09/2018 - 04/2016
3	Hypertrophy 04/2017 - 01/2015
3	Heart Failure 01/2017 - 01/2015
2	Sleep Wake Disorders 01/2019 - 10/2015
2	Hemorrhage 11/2017 - 07/2016
2	Cardiomegaly (Heart Hypertrophy) 04/2017 - 01/2015
2	Hypertension (High Blood Pressure) 01/2017 - 01/2015
2	Myocarditis (Carditis) 11/2016 - 04/2016
2	Fibrosis (Cirrhosis) 04/2016 - 01/2015
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2006 - 08/2003
2	Leukemia 04/2005 - 08/2003
1	Hypertriglyceridemia 01/2019
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2019
1	Abdominal Aortic Aneurysm 09/2018
1	Aneurysm (Aneurysms) 09/2018
1	Keratoacanthoma familial 01/2018
1	Loeys-Dietz Syndrome 01/2018
1	Metabolic Diseases (Metabolic Disease) 11/2017
1	Body Weight (Weight, Body) 11/2017
1	Ureteral Obstruction 01/2017
1	Infections 10/2016
1	Hyperplasia 10/2016
1	Marfan Syndrome (Marfan's Syndrome) 07/2016
1	Premature Aging 05/2016
1	Werner Syndrome (Werner's Syndrome) 05/2016
1	Peripheral Arterial Disease 04/2016
1	Renal Insufficiency (Renal Failure) 04/2016
1	Chronic Limb-Threatening Ischemia 04/2016
1	Cardio-Renal Syndrome 04/2016
1	Narcolepsy 10/2015
1	Cataplexy 10/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2015
1	Coronary Aneurysm (Aneurysm, Coronary) 01/2015
1	Inborn Genetic Diseases (Disease, Hereditary) 04/2005
1	Myeloid Leukemia (Leukemia, Myelocytic) 04/2005
1	Carcinogenesis 04/2005

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 10/2018 - 04/2005
2	ArrestinIBA 06/2021 - 01/2021
2	Tuberculin (PPD)IBA 11/2017 - 07/2016
2	PolyphenolsIBA 11/2016 - 04/2016
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 04/2005 - 08/2003
1	Sterol Regulatory Element Binding Protein 1IBA 01/2019
1	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 01/2019
1	Adenosine (Adenocard)FDA LinkGeneric 01/2019
1	CarbohydratesIBA 01/2019
1	Complement System Proteins (Complement)IBA 10/2018
1	OligodeoxyribonucleotidesIBA 09/2018
1	Transcription Factors (Transcription Factor)IBA 09/2018
1	NF-kappa B (NF-kB)IBA 09/2018
1	OligonucleotidesIBA 09/2018
1	Transforming Growth Factor-beta Type I ReceptorIBA 01/2018
1	Biological ProductsIBA 11/2017
1	Glucose (Dextrose)FDA LinkGeneric 11/2017
1	LeptinIBA 11/2017
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 04/2017
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 04/2017
1	Angiotensin IIIBA 01/2017
1	Protein Subunit VaccinesIBA 01/2017
1	Prostaglandin D2IBA 01/2017
1	LipidsIBA 01/2017
1	VaccinesIBA 01/2017
1	ColforsinIBA 01/2017
1	Monocyte Chemoattractant ProteinsIBA 10/2016
1	cyclopropapyrroloindoleIBA 07/2016
1	Fibrillin-1IBA 07/2016
1	Werner Syndrome HelicaseIBA 05/2016
1	HeterochromatinIBA 05/2016
1	Investigational DrugsIBA 04/2016
1	Angiotensin Receptor AntagonistsIBA 04/2016
1	Irbesartan FDA LinkGeneric 04/2016
1	NADPH Oxidase 4IBA 04/2016
1	Orexin ReceptorsIBA 10/2015
1	Rhodopsin (Visual Purple)IBA 01/2015
1	LuteolinIBA 01/2015
1	Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OHIBA 01/2015
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2015
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 07/2006
1	Tyrosine Kinase InhibitorsIBA 08/2003
1	fms-Like Tyrosine Kinase 3IBA 08/2003
1	GTP 14564IBA 08/2003

Therapy/Procedure

3	Therapeutics 10/2018 - 10/2015
1	Drug Therapy (Chemotherapy) 01/2017
1	Ligation 04/2016
1	Limb Salvage 04/2016
1	Percutaneous Coronary Intervention 01/2015